There are several theories about the causes of fibromyalgia, from hormonal disturbances to stress to genetics. While there is no clear consensus about what causes fibromyalgia, most researchers believe fibromyalgia results not from a single event but from a combination of many physical and emotional stressors.
Other Theories About Causes of Fibromyalgia. Some have speculated that lower levels of a brain neurotransmitter called serotonin leads to lowered pain thresholds or an increased sensitivity to pain. Serotonin is associated with a calming, anxiety-reducing reaction. The lowered pain thresholds in fibromyalgia patients may be caused by the reduced effectiveness of the body’s natural endorphin painkillers and the increased presence of a chemical called “substance P.” Substance P amplifies pain signals.
There have been some studies that link fibromyalgia to sudden trauma to the brain and spinal cord. Keep in mind, though, theories about what causes fibromyalgia are merely speculative.
Who Gets Fibromyalgia? Fibromyalgia is far more common in women than in men. Some interesting studies show that men make serotonin at a much faster rate than women — about 50% faster. That may help explain why fibromyalgia syndrome, or FMS, is more common in women. Another theory states that fibromyalgia is caused by biochemical changes in the body and may be related to hormonal changes or menopause. In addition, some (but not all) people with fibromyalgia have low levels of human growth hormone, which may contribute to the muscle pain.
Does Stress Cause Fibromyalgia? Some researchers theorize that stress or poor physical conditioning are factors in the cause of fibromyalgia. Another theory suggests that muscle “microtrauma” (very slight damage) leads to an ongoing cycle of pain and fatigue. These mechanisms, like all the others, are still unproven for fibromyalgia.